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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5863 | Indinavir sulfate | L735524 sulfate,MK-639 sulfate | SARS-CoV , HIV Protease |
Indinavir sulfate (L735524 sulfate) is a HIV protease inhibitor.It inhibits the HIV-1 protease with an IC50 value of 0.41 nM and Ki value of 0.24 nM. | |||
T4665 | Temsavir | BMS626529 | HIV Protease |
Temsavir (BMS626529) is a novel attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. | |||
T30077 | Anisperimus | LF 150195,LF-150195,LF 15-0195,LF-15-0195,LF15-0195 | Caspase |
Anisperimus (LF 15-0195) is an immunosuppressant that enhances activation-induced T-cell death by promoting caspase-8 and caspase-10 activation at the DISC level, and prevents CNS autoimmunity by promoting the developmen... | |||
T14569 | BI8626 | E1/E2/E3 Enzyme | |
BI8626 is a ubiquitin ligase HUWE1 inhibitor with protective effects against spontaneous desiccation syndrome in NOD/ShiLtj mice.BI8626 inhibits intracellular cholesterol and decreases the expression of phosphorylated ZA... | |||
T37587 | ML 209 | ROR | |
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM... | |||
T10570 | Fostemsavir Tris | BMS-663068 Tris | HIV Protease |
Fostemsavir Tris (BMS-663068 Tris) is the prodrug of BMS-626529,is a oral, safe and effective inhibitor of HIV-1 attachment. It inhibits human immunodeficiency virus type 1 (HIV-1) infection by binding to gp120 and inter... | |||
T5681 | ETHYL CAFFEATE | ETHYL 3,4-DIHYDROXYCINNAMATE | NF-κB , COX , PGE Synthase , NO Synthase |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s... | |||
T6S1885 | Benzoylmesaconine | Mesaconine 14-benzoate | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activi... | |||
T7739 | L-Leucyl-L-Leucine methyl ester hydrochloride | Leu-Leu-ome hydrochloride | Others , Endogenous Metabolite |
L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) is a lysosomal condensation product that cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes. | |||
T2S2173 | (E)-Naringenin chalcone | Isosalipurpol,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone | Others |
Naringenin chalcone (Isosalipurpol) has antiallergic activity Naringenin chalcone suppresses asthmatic symptoms by inhibiting Th2 cytokine production from CD4 T cells. Naringenin chalcone is a potent tomato flavonoid tha... | |||
T81403 | Priliximab | cM-T412,CEN 000029 | |
Priliximab (CEN 000029), an anti-CD4 humanized monoclonal antibody, binds to CD4 receptors on T cells, leading to a significant and sustained decrease in circulating CD4+ T cells. This property renders it useful in the s... | |||
T82743 | CFP10 (71–85) | ||
CFP10 (71–85) is an immunologically active peptide that induces IFN-γ production and cytotoxic T lymphocyte (CTL) activity in CD4+ and CD8+ T cells from individuals with diverse MHC class II and I expression profiles. | |||
T70065 | JNJ-61803534 | ||
JNJ-61803534 is a potent, orally active RORγt inverse agonist, demonstrating anti-inflammatory activity through inhibition of IL-17A production in human CD4+ T cells under Th17 differentiation conditions, with an IC50 of... | |||
T78275 | Ivuxolimab | ||
Ivuxolimab, an OX40 (also known as CD134; TNFRSF4) agonist monoclonal antibody, targets a costimulatory receptor found on activated CD4+ and CD8+ T cells. It demonstrates antitumor properties and may exhibit immunostimul... | |||
T78291 | Tregalizumab | BT-061 | |
Tregalizumab, a humanized IgG1-type monoclonal antibody targeting CD4, selectively activates regulatory T cells (Tregs) with suppressive functions in vitro and has potential applications in researching autoimmune disease... | |||
T40590 | NY-ESO-1 (87-111) | ||
NY-ESO-1 (87-111) is a pan-MHC class II-restricted peptide that interacts with various HLA-DR and HLA-DP4 molecules, inducing activation of CD4+ T cells with Th1-type and Th-2/Th0-type responses, when presented in conjun... | |||
T83724 | TPP-1 hydrochloride | Targeting PD-L1 Peptide | |
TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration o... | |||
T81308 | RDN2150 | ||
RDN2150 (Compound 25), a ZAP-70 inhibitor with an IC50 of 14.6 nM, covalently binds to the C346 residue of ZAP-70, suppressing the expression of CD25 and CD69 and inhibiting the activation of CD4+ T cells, making it suit... | |||
T25109 | ARN-6039 | ARN 6039,ARN6039 | |
ARN-6039 is an orally available inverse agonist of RORγ for Autoimmune Neuroinflammatory Demyelinating Disease. The activity of ARN-6039 against RORγ was demonstrated in a RORγ-activated IL-17A Prom/LUCPorter assay in HE... | |||
T21441 | Prostratin | 12-Deoxyphorbol-13-acetate | |
Prostratin, a protein kinase C activator, has been shown to exhibit promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. Prostratin has the potential to be useful in the treatmen... |